Conclusion as mitochondria are a major source of ros the present review summarizes the role of mitochondrial oxidative stress in ash and nash and presents emerging data indicating the need to preserve mitochondrial antioxidant balance as a potential approach for the treatment of human fatty liver disease which may pave the way for the design . This review article will discuss the following topics regarding the pathobiology and molecular mechanisms responsible for fatty liver disease 1 the two hit or multi hit hypothesis 2 the role of mitochondrial bioenergetic defects and oxidant stress 3 the interplay between no and mitochondria in fatty liver disease 4 . Mitochondrial oxidative stress and antioxidants balance in fatty liver disease carmen garcia ruiz12 and jose c fernandez checa123 fatty liver disease is one of the most prevalent forms of chronic liver disease that encompasses both alcoholic liver disease ald and nonalcoholic fatty liver disease nafld. Mitochondrial oxidative stress and antioxidants balance in fatty liver disease article pdf available october 2018 with 121 reads how we measure reads. 32 nonalcoholic fatty liver disease and oxidative stress compared to the non nafld the nafld group had significantly higher levels of glutathione peroxidase gpx and mitochondrial dna copy number table 1the two groups did not differ significantly in other oxidative stress markers such as tbars thiol and sod
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